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Chloroquine and most other chemoprophylactic drugs have proved to be ineffective against falciparum malaria in Thailand. Tourists visiting these endemic areas are rather recommended to take general precautions against mosquito bite. After sunset, they should stay in screened quarters or mosquito nets, wear longsleeve shirts and pants, and may apply mosquito repellents. Those who develop fever within two weeks of entry to risk areas should seek prompt medical examination and treatment.

Japanese encephalitis

This viral infection of the brain, is contracted through the bite of mosquitoes that prevail in rural agricultural areas. It is found in many Eastern and Southeastern Asian countries, primarily in the rural and suburban areas. Similar to malaria, the disease can be prevented by avoiding mosquito bite during the night time. Travellers who plan to spend their time exposing to rural environment in these regions for over several months are recommended to take Japanese encephalitis vaccination before entry.

Dengue fever and dengue hemorrhagic fever

These diseases are endemic in Southeast Asia. They are caused by dengue virus from the bite of aedes mosquito that lives in the houses and their neighbourbood. This mosquito bites during the day time. Dengue infection in local people, mostly children, often results in fever with bleeding in the skin and other organs (dengue hemorrhagic fever) which is sometime fatal; but for travellers from non-endemic areas, the infection usually minifests as fever with rash in the skin, severe headache and muscle and pains (dengue fever), which is usually non-fatal.

Dengue infection is common in the rainy season (approximately May to September in Thailand) when aedes mosquito is abundant. Travellers visiting local households or their vicinity, especially in the rainy season, should be using mosquito repellent even in the day time. Ones who are ill with symptoms suspected of dengue infection should seek medical consultation to establish the cause of the illness.